PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15777842-3 2005 Enzymes of this class, such as prolyl-4-hydroxylases, mediate the oxygen and iron-dependent degradation of the hypoxia inducible factor HIF-1alpha, which requires the E3 ubiquitin ligase activity of pVHL. Iron 77-81 hypoxia inducible factor 1 subunit alpha Homo sapiens 136-146