Pub. Date : 2004 Nov
PMID : 15666830
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously reported that the protein kinase C ligand 12-O-tetradecanoyphorbol-13-acetate (TPA) inhibited the angiotensin II (AII) stimulated CYP11B2 gene expression in the adrenocortical H295R cell line. | Tetradecanoylphorbol Acetate | angiotensinogen | Homo sapiens |
| 2 | We have previously reported that the protein kinase C ligand 12-O-tetradecanoyphorbol-13-acetate (TPA) inhibited the angiotensin II (AII) stimulated CYP11B2 gene expression in the adrenocortical H295R cell line. | Tetradecanoylphorbol Acetate | angiotensinogen | Homo sapiens |
| 3 | Taken together these results suggest that TPA inhibits the AII-dependent activation of CYP11B2 via the p44/42 MAPK signaling pathway leading to an increase of the level of nuclear JunB. | Tetradecanoylphorbol Acetate | angiotensinogen | Homo sapiens |