Protein Name angiotensinogen
Organism Homo sapiens
Gene ID 183
Gene Symbol


UniProt P01019 (ANGT_HUMAN), B0ZBE2 (B0ZBE2_HUMAN), B2R5S1 (B2R5S1_HUMAN)
Relationships Total Number of functionally related compound(s) : 2109
Total Number of Articles : 6104


Gene Summary

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]

  • angiotensinogen
  • alpha-1 antiproteinase, antitrypsin
  • angiotensin I
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