Title : Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.

Pub. Date : 2005 Feb 1

PMID : 15664814






1 Functional Relationships(s)
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1 Isozymes hCA I and II are best inhibited by chlorate, perchlorate, and silicate, together with the anions structurally related to sulfate, sulfamate, and sulfamidate, but sulfate itself is a weak inhibitor (inhibition constant of 74 mM against hCA I and 183 mM against hCA II). Chlorates cytochrome P450 family 24 subfamily A member 1 Homo sapiens