Pub. Date : 2005 May
PMID : 15637112
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |
| 2 | Tempol or tiron (superoxide scavengers) increased flow-induced dilation in vessels of Mn-SOD+/- mice. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |
| 3 | Superoxide levels in the arteries of Mn-SOD+/- mice were significantly increased. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |
| 4 | We conclude that an increased concentration of superoxide due to reduced activity of Mn-SOD, which inactivates nitric oxide and inhibits eNOS activity, contributes to the impaired vasodilator function of isolated mesenteric arteries of Mn-SOD+/- mice. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |
| 5 | We conclude that an increased concentration of superoxide due to reduced activity of Mn-SOD, which inactivates nitric oxide and inhibits eNOS activity, contributes to the impaired vasodilator function of isolated mesenteric arteries of Mn-SOD+/- mice. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |