Title : Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice.

Pub. Date : 2005 May

PMID : 15637112






5 Functional Relationships(s)
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1 Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. Superoxides superoxide dismutase 2, mitochondrial Mus musculus
2 Tempol or tiron (superoxide scavengers) increased flow-induced dilation in vessels of Mn-SOD+/- mice. Superoxides superoxide dismutase 2, mitochondrial Mus musculus
3 Superoxide levels in the arteries of Mn-SOD+/- mice were significantly increased. Superoxides superoxide dismutase 2, mitochondrial Mus musculus
4 We conclude that an increased concentration of superoxide due to reduced activity of Mn-SOD, which inactivates nitric oxide and inhibits eNOS activity, contributes to the impaired vasodilator function of isolated mesenteric arteries of Mn-SOD+/- mice. Superoxides superoxide dismutase 2, mitochondrial Mus musculus
5 We conclude that an increased concentration of superoxide due to reduced activity of Mn-SOD, which inactivates nitric oxide and inhibits eNOS activity, contributes to the impaired vasodilator function of isolated mesenteric arteries of Mn-SOD+/- mice. Superoxides superoxide dismutase 2, mitochondrial Mus musculus