PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15637112-0 2005 Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. Superoxides 10-20 superoxide dismutase 2, mitochondrial Mus musculus 88-94 15637112-5 2005 Tempol or tiron (superoxide scavengers) increased flow-induced dilation in vessels of Mn-SOD+/- mice. Superoxides 17-27 superoxide dismutase 2, mitochondrial Mus musculus 86-95 15637112-7 2005 Superoxide levels in the arteries of Mn-SOD+/- mice were significantly increased. Superoxides 0-10 superoxide dismutase 2, mitochondrial Mus musculus 37-43 15637112-11 2005 We conclude that an increased concentration of superoxide due to reduced activity of Mn-SOD, which inactivates nitric oxide and inhibits eNOS activity, contributes to the impaired vasodilator function of isolated mesenteric arteries of Mn-SOD+/- mice. Superoxides 47-57 superoxide dismutase 2, mitochondrial Mus musculus 85-91 15637112-11 2005 We conclude that an increased concentration of superoxide due to reduced activity of Mn-SOD, which inactivates nitric oxide and inhibits eNOS activity, contributes to the impaired vasodilator function of isolated mesenteric arteries of Mn-SOD+/- mice. Superoxides 47-57 superoxide dismutase 2, mitochondrial Mus musculus 236-245