Pub. Date : 2005
PMID : 15607575
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Plasma PAI-1 correlates inversely with the ability of insulin infusion to suppress free fatty acid levels. | Fatty Acids, Nonesterified | serpin family E member 1 | Homo sapiens |
| 2 | Moreover, infusion of triglycerides with heparin - inducing a marked increase in free fatty acids - has been shown to induce a rapid increase in plasma PAI-1. | Fatty Acids, Nonesterified | serpin family E member 1 | Homo sapiens |
| 3 | Plasma PAI-1 can be decreased in insulin resistant subjects by improving adipocyte insulin sensitivity (with weight loss and thiazolidinediones), by consuming a very-low-fat diet that minimizes postprandial free fatty acid flux, and by administering activators of AMP-activated kinase (e.g., metformin), which can be expected to lessen tissue DAG synthesis. | Fatty Acids, Nonesterified | serpin family E member 1 | Homo sapiens |