PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15607575-4 2005 Plasma PAI-1 correlates inversely with the ability of insulin infusion to suppress free fatty acid levels. Fatty Acids, Nonesterified 83-98 serpin family E member 1 Homo sapiens 7-12 15607575-5 2005 Moreover, infusion of triglycerides with heparin - inducing a marked increase in free fatty acids - has been shown to induce a rapid increase in plasma PAI-1. Fatty Acids, Nonesterified 81-97 serpin family E member 1 Homo sapiens 152-157 15607575-9 2005 Plasma PAI-1 can be decreased in insulin resistant subjects by improving adipocyte insulin sensitivity (with weight loss and thiazolidinediones), by consuming a very-low-fat diet that minimizes postprandial free fatty acid flux, and by administering activators of AMP-activated kinase (e.g., metformin), which can be expected to lessen tissue DAG synthesis. Fatty Acids, Nonesterified 207-222 serpin family E member 1 Homo sapiens 7-12