Title : The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics.

Pub. Date : 2004 Nov

PMID : 15607480






3 Functional Relationships(s)
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1 Moreover, such binding in SERT-rich brain regions is reduced significantly by pretreatment with either citalopram or the cold compound itself, but not by nisoxetine or GBR 12935, thus demonstrating that [(11)C]AFE binding in the rat brain is saturable, specific and selective for the SERT. Citalopram solute carrier family 6 member 4 Rattus norvegicus
2 Moreover, such binding in SERT-rich brain regions is reduced significantly by pretreatment with either citalopram or the cold compound itself, but not by nisoxetine or GBR 12935, thus demonstrating that [(11)C]AFE binding in the rat brain is saturable, specific and selective for the SERT. Citalopram solute carrier family 6 member 4 Rattus norvegicus
3 Pretreatment of the baboon with citalopram (4 mg/kg) 20 min before radioactivity injection reduced the binding of [(11)C]AFE in all SERT-containing brain regions to the level in the cerebellum. Citalopram solute carrier family 6 member 4 Rattus norvegicus