Title : Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

Pub. Date : 2005 Mar

PMID : 15576463






4 Functional Relationships(s)
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1 Inhibition of mTOR/S6K1 by rapamycin increased insulin-stimulated glucose transport by as much as 45% in 3T3-L1 adipocytes. Sirolimus insulin Homo sapiens
2 However, insulin-induced activation of Akt was increased by rapamycin. Sirolimus insulin Homo sapiens
3 As in murine cells, rapamycin treatment of human adipocytes inhibited S6K1, blunted Ser636/639 phosphorylation of IRS-1, leading to increased Akt activation and glucose uptake by insulin. Sirolimus insulin Homo sapiens
4 Further studies in 3T3-L1 adipocytes revealed that rapamycin prevented the relocalization of IRS-1 from the low-density membranes to the cytosol in response to insulin. Sirolimus insulin Homo sapiens