Pub. Date : 2005 Mar
PMID : 15557344
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This investigation evaluated alfentanil metabolism in vitro to noralfentanil and N-phenylpropionamide, by expressed CYP3A5 and CYP3A7 in addition to CYP3A4, with and without coexpressed or exogenous cytochrome b(5). | Alfentanil | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | These results demonstrate that alfentanil is a substrate for CYP3A5 in addition to CYP3A4, and the effects of the CYP3A inhibitors troleandomycin and ketoconazole are CYP3A enzyme-selective. | Alfentanil | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | Polymorphic CYP3A5 expression may contribute to inter-individual variability in alfentanil metabolism. | Alfentanil | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |