PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15557344-4 2005 This investigation evaluated alfentanil metabolism in vitro to noralfentanil and N-phenylpropionamide, by expressed CYP3A5 and CYP3A7 in addition to CYP3A4, with and without coexpressed or exogenous cytochrome b(5). Alfentanil 29-39 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 116-122 15557344-10 2005 These results demonstrate that alfentanil is a substrate for CYP3A5 in addition to CYP3A4, and the effects of the CYP3A inhibitors troleandomycin and ketoconazole are CYP3A enzyme-selective. Alfentanil 31-41 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 61-67 15557344-12 2005 Polymorphic CYP3A5 expression may contribute to inter-individual variability in alfentanil metabolism. Alfentanil 80-90 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 12-18