Pub. Date : 2005 Feb 4
PMID : 15557278
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now show that: 1) Trio and another Rac GEF (Tiam1) act by inducing GDP to GTP exchange on prenylated Rac1-GDP and that our earlier assertion that activation is GTP-independent is explained by contamination of p67phox preparations with GTP and/or ATP. | Guanosine Diphosphate | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |
| 2 | We now show that: 1) Trio and another Rac GEF (Tiam1) act by inducing GDP to GTP exchange on prenylated Rac1-GDP and that our earlier assertion that activation is GTP-independent is explained by contamination of p67phox preparations with GTP and/or ATP. | Guanosine Diphosphate | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |
| 3 | 4) The ability of ATP to support GEF-induced oxidase activation is explained by ATP serving as a gamma-phosphoryl donor for a membrane-localized nucleoside diphosphate kinase (NDPK), converting GDP to GTP. | Guanosine Diphosphate | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |
| 4 | 7) Free GDP is derived exclusively by dissociation from prenylated Rac1-GDP, mediated by GEF. | Guanosine Diphosphate | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |
| 5 | NDPK and GEF appear to be functionally linked in the sense that the availability of GDP, serving as substrate for NDPK, is dependent on the level of activity of GEF. | Guanosine Diphosphate | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |
| 6 | NDPK and GEF appear to be functionally linked in the sense that the availability of GDP, serving as substrate for NDPK, is dependent on the level of activity of GEF. | Guanosine Diphosphate | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |