Title : Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis.

Pub. Date : 2004 Dec 20

PMID : 15546740






1 Functional Relationships(s)
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1 This study suggested that interaction of both 4-phenoxy and phenyloxazole substituents of these ligands with F272 and M279 in mouse PPARalpha leads to the species-specific divergence in ligand binding. 4-phenoxy peroxisome proliferator activated receptor alpha Mus musculus