Pub. Date : 2005 Jan
PMID : 15494464
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 2 | Our objective is to test the hypothesis that, in human luteinized granulosa cells, epidermal growth factor (EGF) works through the MAPK signaling pathway and inhibition of EGF receptor by a specific tyrosine kinase inhibitor, tyrphostin 51, will inhibit the activation of MAPK and induce apoptosis. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 3 | Blockage of EGF receptor by tyrphostin 51 reduced the MAPK activity and inhibited phosphorylation and nuclear translocation of activated MAPK. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |