Title : Extracellular superoxide dismutase functions as a major repressor of hypoxia-induced erythropoietin gene expression.

Pub. Date : 2005 Jan

PMID : 15375030






2 Functional Relationships(s)
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1 Here we report that extracellular superoxide dismutase (EC-SOD) plays a major role in regulating the magnitude of hypoxia-induced erythropoietin (Epo) gene expression, thus implicating superoxide as an intermediary signal transduction molecule critical to this process. Superoxides superoxide dismutase 3, extracellular Mus musculus
2 We conclude that EC-SOD functions as a major repressor of hypoxia-induced Epo gene expression, which implicates superoxide as a signaling intermediate whose downstream effects, at least in part, may be mediated by HIF-1alpha. Superoxides superoxide dismutase 3, extracellular Mus musculus