PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15375030-2 2005 Here we report that extracellular superoxide dismutase (EC-SOD) plays a major role in regulating the magnitude of hypoxia-induced erythropoietin (Epo) gene expression, thus implicating superoxide as an intermediary signal transduction molecule critical to this process. Superoxides 34-44 superoxide dismutase 3, extracellular Mus musculus 56-62 15375030-8 2005 We conclude that EC-SOD functions as a major repressor of hypoxia-induced Epo gene expression, which implicates superoxide as a signaling intermediate whose downstream effects, at least in part, may be mediated by HIF-1alpha. Superoxides 112-122 superoxide dismutase 3, extracellular Mus musculus 17-23