Title : Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3.

Pub. Date : 2004 Nov

PMID : 15371330






6 Functional Relationships(s)
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Protein Name
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1 H2S treatment increased the activities of ERK and p38 mitogen-activated protein kinase (MAPK), but not c-Jun N-terminal kinase activity. Hydrogen Sulfide mitogen-activated protein kinase 1 Homo sapiens
2 H2S treatment increased the activities of ERK and p38 mitogen-activated protein kinase (MAPK), but not c-Jun N-terminal kinase activity. Hydrogen Sulfide mitogen-activated protein kinase 1 Homo sapiens
3 Suppression of extracellular signal-regulated kinase (ERK) activity, but not of p38 activity, inhibited the H2S-induced apoptosis of HASMCs. Hydrogen Sulfide mitogen-activated protein kinase 1 Homo sapiens
4 Suppression of extracellular signal-regulated kinase (ERK) activity, but not of p38 activity, inhibited the H2S-induced apoptosis of HASMCs. Hydrogen Sulfide mitogen-activated protein kinase 1 Homo sapiens
5 The activation of ERK by H2S in HASMCs was accompanied by increased caspase-3 activity. Hydrogen Sulfide mitogen-activated protein kinase 1 Homo sapiens
6 Of the three investigated MAPKs, only ERK played an active role in mediating H2S-induced apoptosis of HASMCs by activating caspase-3. Hydrogen Sulfide mitogen-activated protein kinase 1 Homo sapiens