Title : In silico activation of Src tyrosine kinase reveals the molecular basis for intramolecular autophosphorylation.

Pub. Date : 2004 Oct

PMID : 15363460






1 Functional Relationships(s)
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1 Rather unexpectedly, however, swinging of the lobes situated Tyr-416 in a suitable position for intramolecular autophosphorylation, and further simulation of Tyr-416-phosphorylated Src in the presence of ADP did then result in a conformational change that placed the activation loop in a position similar to that found in the active open conformation of Lck. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens