Title : HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study.

Pub. Date : 2004 Sep 1

PMID : 15355892






2 Functional Relationships(s)
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1 The present study examined whether HER-2 gene amplification or HER-1 expression predicted response to tamoxifen. Tamoxifen epidermal growth factor receptor Homo sapiens
2 CONCLUSION: Patients with HER-2 amplification and HER-1 expression had lower ER levels and were modestly less responsive to tamoxifen, suggesting that molecular events in addition to those involving the ErbB receptors are important in determining the endocrine-resistant phenotype. Tamoxifen epidermal growth factor receptor Homo sapiens