Pub. Date : 2004 Sep
PMID : 15329596
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway. | Sevoflurane | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | RESULTS: Sevoflurane inhibited activation of the transcription factor AP-1. | Sevoflurane | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Sevoflurane-mediated suppression of AP-1 could be observed in primary CD3 lymphocytes from healthy volunteers, was time-dependent and concentration-dependent, and occurred at concentrations that are clinically achieved. | Sevoflurane | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | CONCLUSION: The data demonstrate that sevoflurane is a specific inhibitor of AP-1 and may thus provide a molecular mechanism for the antiinflammatory effects associated with sevoflurane administration. | Sevoflurane | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 5 | CONCLUSION: The data demonstrate that sevoflurane is a specific inhibitor of AP-1 and may thus provide a molecular mechanism for the antiinflammatory effects associated with sevoflurane administration. | Sevoflurane | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |