Pub. Date : 2004 Aug 15
PMID : 15313918
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 2 | We tested the hypothesis that SFN acts as an inhibitor of histone deacetylase (HDAC). | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 3 | We tested the hypothesis that SFN acts as an inhibitor of histone deacetylase (HDAC). | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 4 | Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells: SFN dose-dependently increased TOPflash reporter activity and inhibited HDAC activity, there was an increase in acetylated histones and in p21(Cip1/Waf1), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter. | sulforaphane | histone deacetylase 9 | Homo sapiens |