Title : The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.

Pub. Date : 2004 Aug

PMID : 15255937






3 Functional Relationships(s)
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1 The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone mitogen-activated protein kinase kinase 7 Homo sapiens
2 In contrast to its effect in vitro, treatment of neurons with GW5074 causes c-Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf-MEK-ERK pathway. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone mitogen-activated protein kinase kinase 7 Homo sapiens
3 PD98059 and U0126, two distinct inhibitors of MEK, block the activation of ERK by GW5074 but have no effect on its ability to prevent cell death. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone mitogen-activated protein kinase kinase 7 Homo sapiens