Title : Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate.

Pub. Date : 2004 Feb

PMID : 15228219






1 Functional Relationships(s)
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1 The indispensable branched-chain amino acid leucine acts as a key regulator of mRNA translation by modulating the phosphorylation of proteins that represent important control points in translation initiation, including the translational repressor, eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (S6K1). branched-chain amino acid leucine ribosomal protein S6 kinase B1 Homo sapiens