Title : A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

Pub. Date : 2004 Aug

PMID : 15208781






1 Functional Relationships(s)
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1 We show that the risk allele, which is present in approximately 17% of white individuals from the general population and in approximately 28% of white individuals with RA, disrupts the P1 proline-rich motif that is important for interaction with Csk, potentially altering these proteins" normal function as negative regulators of T-cell activation. Proline C-terminal Src kinase Homo sapiens