| Protein Name | C-terminal Src kinase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1445 |
| Gene Symbol | CSK |
| UniProt | P41240 (CSK_HUMAN), B2R6Q4 (B2R6Q4_HUMAN), A8K3B6 (A8K3B6_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
196
Total Number of Articles : 304 |
Description |
C-terminal Src kinase |
| Gene Summary |
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017] |
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