Pub. Date : 2004 May 1
PMID : 15126635
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. | Glycosaminoglycans | NEDD4 E3 ubiquitin protein ligase | Homo sapiens |
| 2 | The Gag proteins of oncoretroviruses possess a PPxY motif that recruits a ubiquitin ligase from the Nedd4 family, whereas those of the human immunodeficiency virus interact through a PTAP motif with Tsg101, a protein of the ESCRT-1 complex. | Glycosaminoglycans | NEDD4 E3 ubiquitin protein ligase | Homo sapiens |
| 3 | We show that Nedd4.1, but not Nedd4.2, is recruited by the PPPY motif of Gag and subsequently catalyzes Gag ubiquitination. | Glycosaminoglycans | NEDD4 E3 ubiquitin protein ligase | Homo sapiens |
| 4 | We show that Nedd4.1, but not Nedd4.2, is recruited by the PPPY motif of Gag and subsequently catalyzes Gag ubiquitination. | Glycosaminoglycans | NEDD4 E3 ubiquitin protein ligase | Homo sapiens |
| 5 | We also demonstrate that Gag interacts first with Nedd4.1 at the plasma membrane and then with Tsg101 in late endosomes/MVBs. | Glycosaminoglycans | NEDD4 E3 ubiquitin protein ligase | Homo sapiens |
| 6 | Our findings indicate that Nedd4.1 and Tsg101 act successively in the assembly process of HTLV-1 to ensure proper Gag trafficking through the endocytic pathway up to late endosomes where the late steps of retroviral release occur. | Glycosaminoglycans | NEDD4 E3 ubiquitin protein ligase | Homo sapiens |