Protein Name | NEDD4 E3 ubiquitin protein ligase |
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Organism | Homo sapiens |
Gene ID | 4734 |
Gene Symbol | NEDD4 |
UniProt | P46934 (NEDD4_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
117
Total Number of Articles : 122 |
Description |
NEDD4 E3 ubiquitin protein ligase |
Gene Summary |
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016] |
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