Protein Name NEDD4 E3 ubiquitin protein ligase
Organism Homo sapiens
Gene ID 4734
Gene Symbol

NEDD4

UniProt P46934 (NEDD4_HUMAN)
Relationships Total Number of functionally related compound(s) : 117
Total Number of Articles : 122
Description

NEDD4 E3 ubiquitin protein ligase

Gene Summary

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

synonyms
  • E3 ubiquitin-protein ligase NEDD4
  • HECT-type E3 ubiquitin transferase NEDD4
  • cell proliferation-inducing gene 53 protein
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Properties