Title : Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.

Pub. Date : 2004 Jun 25

PMID : 15078870






2 Functional Relationships(s)
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1 In the x-ray crystal structure of LTA(4) hydrolase, Arg(563) and Lys(565) are found at the entrance of the active center. Arginine leukotriene A4 hydrolase Homo sapiens
2 In conclusion, Arg(563) and Lys(565) possess distinct roles as carboxylate recognition sites for two chemically different substrates, each of which is turned over in separate enzymatic reactions catalyzed by LTA(4) hydrolase. Arginine leukotriene A4 hydrolase Homo sapiens