Protein Name leukotriene A4 hydrolase
Organism Homo sapiens
Gene ID 4048
Gene Symbol

LTA4H

UniProt P09960 (LKHA4_HUMAN), A0A140VK27 (A0A140VK27_HUMAN)
Relationships Total Number of functionally related compound(s) : 185
Total Number of Articles : 205
Description

leukotriene A4 hydrolase

Gene Summary

The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

synonyms
  • leukotriene A-4 hydrolase
  • LTA-4 hydrolase
  • testicular secretory protein Li 27
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Properties