Title : Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB.

Pub. Date : 2004 Mar 30

PMID : 15010209






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 LPS-induced DNA binding of p65/p50 was similarly enhanced by Mn and was decreased by mutant IkappaBalpha. lps nuclear factor kappa B subunit 1 Homo sapiens
2 These data indicate that Mn augments LPS-induced expression of NOS2 in C6 cells by increasing mitochondrial ROS and activation of NF-kappaB. lps nuclear factor kappa B subunit 1 Homo sapiens