Pub. Date : 2003 Dec
PMID : 14991082
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE AND DESIGN: To determine the effect of FK506 (tacrolimus) on paw inflammation, TNF-alpha expression in joint, and bone and cartilage destruction in type II collagen-induced arthritis (CIA) model in rats. | Tacrolimus | tumor necrosis factor | Rattus norvegicus |
| 2 | FK506 (3.2 mg/kg) markedly reduced TNF-alpha expression. | Tacrolimus | tumor necrosis factor | Rattus norvegicus |
| 3 | CONCLUSION: These results show that FK506 is effective in suppressing inflammation, TNF-alpha expression in joint, and damage to bone and cartilage in rat CIA, and may be useful in the treatment of rheumatoid arthritis. | Tacrolimus | tumor necrosis factor | Rattus norvegicus |