PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14991082-1	2003	OBJECTIVE AND DESIGN: To determine the effect of FK506 (tacrolimus) on paw inflammation, TNF-alpha expression in joint, and bone and cartilage destruction in type II collagen-induced arthritis (CIA) model in rats.	Tacrolimus	56-66	tumor necrosis factor	Rattus norvegicus	89-98	
14991082-10	2003	FK506 (3.2 mg/kg) markedly reduced TNF-alpha expression.	Tacrolimus	0-5	tumor necrosis factor	Rattus norvegicus	35-44	
14991082-14	2003	CONCLUSION: These results show that FK506 is effective in suppressing inflammation, TNF-alpha expression in joint, and damage to bone and cartilage in rat CIA, and may be useful in the treatment of rheumatoid arthritis.	Tacrolimus	36-41	tumor necrosis factor	Rattus norvegicus	84-93