Pub. Date : 2004 Feb 15
PMID : 14973114
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclooxygenase-2 is essential for HER2/neu to suppress N- (4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells. | Fenretinide | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | We show that HER2/neu uses Akt to induce cyclooxygenase-2 (COX-2) expression and that inhibition of Akt or COX-2 increases 4-HPR-induced apoptosis and nitric oxide production. | Fenretinide | prostaglandin-endoperoxide synthase 2 | Homo sapiens |