Title : Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

Pub. Date : 2004 Feb 1

PMID : 14871963






1 Functional Relationships(s)
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1 The underlying mechanism is probably a shift of the cytotoxic locus of temozolomide to N(7)-methylguanine and N(3)-methyladenine, which are repaired by the base excision repair pathway in which PARP-1 actively participates. 3-methyladenine poly(ADP-ribose) polymerase 1 Homo sapiens