PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14871963-11 2004 The underlying mechanism is probably a shift of the cytotoxic locus of temozolomide to N(7)-methylguanine and N(3)-methyladenine, which are repaired by the base excision repair pathway in which PARP-1 actively participates. 3-methyladenine 110-128 poly(ADP-ribose) polymerase 1 Homo sapiens 194-200