Pub. Date : 2003 Nov
PMID : 14651779
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fever after zoledronic acid administration is due to increase in TNF-alpha and IL-6. | Zoledronic Acid | interleukin 6 | Homo sapiens |
| 2 | The aim of this study was to define the role of the main cytokines of the acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) involved in the pathogenesis of zoledronic acid-induced fever. | Zoledronic Acid | interleukin 6 | Homo sapiens |
| 3 | The aim of this study was to define the role of the main cytokines of the acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) involved in the pathogenesis of zoledronic acid-induced fever. | Zoledronic Acid | interleukin 6 | Homo sapiens |
| 4 | IL-6 levels increased significantly 1 day after the infusion (p = 0.007), returning to values similar to the median basal values 2 days after zoledronic acid administration. | Zoledronic Acid | interleukin 6 | Homo sapiens |
| 5 | Our results show that zoledronic acid induces transient TNF-alpha and IL-6 increases and that these increases are higher in patients who have developed fever, suggesting that these cytokines could be responsible for fever pathogenesis. | Zoledronic Acid | interleukin 6 | Homo sapiens |