PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14651779-0	2003	Fever after zoledronic acid administration is due to increase in TNF-alpha and IL-6.	Zoledronic Acid	12-27	interleukin 6	Homo sapiens	79-83	
14651779-2	2003	The aim of this study was to define the role of the main cytokines of the acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) involved in the pathogenesis of zoledronic acid-induced fever.	Zoledronic Acid	192-207	interleukin 6	Homo sapiens	95-108	
14651779-2	2003	The aim of this study was to define the role of the main cytokines of the acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) involved in the pathogenesis of zoledronic acid-induced fever.	Zoledronic Acid	192-207	interleukin 6	Homo sapiens	110-114	
14651779-7	2003	IL-6 levels increased significantly 1 day after the infusion (p = 0.007), returning to values similar to the median basal values 2 days after zoledronic acid administration.	Zoledronic Acid	142-157	interleukin 6	Homo sapiens	0-4	
14651779-10	2003	Our results show that zoledronic acid induces transient TNF-alpha and IL-6 increases and that these increases are higher in patients who have developed fever, suggesting that these cytokines could be responsible for fever pathogenesis.	Zoledronic Acid	22-37	interleukin 6	Homo sapiens	70-74