Title : Nicotine enhances angiotensin II-induced mitogenic response in vascular smooth muscle cells and fibroblasts.

Pub. Date : 2004 Jan

PMID : 14592853






1 Functional Relationships(s)
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1 We examined the potential possibility of an interaction between nicotine, a major component of cigarette smoke, and angiotensin II (Ang II), which plays an important role in the pathogenesis of cardiovascular diseases characterized by Ang II type 1 (AT1) receptor-mediated abnormal growth of vascular smooth muscle cells (VSMC) and fibroblasts. Nicotine angiotensin II receptor, type 1a Rattus norvegicus