Title : Inactivation of the small GTPase Rac1 protects the liver from ischemia/reperfusion injury in the rat.

Pub. Date : 2003 Sep

PMID : 14555937






1 Functional Relationships(s)
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1 CONCLUSION: We conclude that Rac1 is required in ROS generation and NF-kappaB activation after hepatic I/R in vivo, and that inactivation of NF-kappaB in NPCs and suppression of ROS generation in NPCs and hepatocytes possibly account for the protective effect of N17Rac1 in this study. Reactive Oxygen Species Rac family small GTPase 1 Rattus norvegicus