Protein Name Rac family small GTPase 1
Organism Rattus norvegicus
Gene ID 363875
Gene Symbol

Rac1

UniProt Q6RUV5 (RAC1_RAT)
Relationships Total Number of functionally related compound(s) : 259
Total Number of Articles : 321
Description

Rac family small GTPase 1

Gene Summary

Enables several functions, including GTP binding activity; Rho GDP-dissociation inhibitor binding activity; and enzyme binding activity. Involved in several processes, including actin cytoskeleton organization; bone resorption; and positive regulation of plasma membrane bounded cell projection assembly. Located in Golgi membrane and cytosol. Is active in GABA-ergic synapse. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • ras-related C3 botulinum toxin substrate 1
  • p21-Rac1
  • ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
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Properties