Title : Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.

Pub. Date : 2003 Dec 12

PMID : 14522966






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A rapid decrease of phosphorylated ERK1/2 and a marked increase of p38 MAPK phosphorylation were observed within 10 min after phytosphingosine treatment. phytosphingosine mitogen-activated protein kinase 3 Homo sapiens
2 Activation of ERK1/2 by pretreatment with phorbol 12-myristate 13-acetate or forced expression of ERK1/2 attenuated phytosphingosine-induced caspase-8 activation. phytosphingosine mitogen-activated protein kinase 3 Homo sapiens
3 Activation of ERK1/2 by pretreatment with phorbol 12-myristate 13-acetate or forced expression of ERK1/2 attenuated phytosphingosine-induced caspase-8 activation. phytosphingosine mitogen-activated protein kinase 3 Homo sapiens
4 However, Bax translocation and caspase-9 activation was unaffected, indicating that down-regulation of the ERK activity is specifically required for the phytosphingosine-induced caspase-8-dependent cell death pathway. phytosphingosine mitogen-activated protein kinase 3 Homo sapiens
5 Our results suggest that phytosphingosine can utilize two different MAPK signaling pathways for amplifying the apoptosis cascade, enhancing the understanding of the molecular mechanisms utilized by naturally occurring metabolites to regulate cell death. phytosphingosine mitogen-activated protein kinase 3 Homo sapiens