Title : Novel strategy for DNA aptamers inhibiting enzymatic activity using algorithm mimicking evolution.

Pub. Date : 2003

PMID : 14510452






1 Functional Relationships(s)
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1 For screening, we first randomly designed and synthesized ten 15-mer oligonucleotides supposed to form G-quartet structure and then measured the inhibitory activity for thrombin. Oligonucleotides coagulation factor II, thrombin Homo sapiens