Pub. Date : 1992 Sep 1
PMID : 1382425
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protein tyrosine kinase (PTK) blockers (tyrphostins) inhibit in a dose-dependent fashion thrombin-induced aggregation and serotonin release with IC50 values in the 10-35 microM concentration range. | Tyrphostins | coagulation factor II, thrombin | Homo sapiens |
| 2 | Tyrphostins decreased [32P]phosphatidic acid production induced by thrombin, although never by more than 50%, and only delayed the peak of diacylglycerol, suggesting that phospholipase C was still activated. | Tyrphostins | coagulation factor II, thrombin | Homo sapiens |
| 3 | Tyrphostins inhibited the thrombin-elicited early phosphorylation of p43 and p20, substrates for protein kinase C (PKC) and myosin light chain kinase, respectively, at short times of activation. | Tyrphostins | coagulation factor II, thrombin | Homo sapiens |
| 4 | The ability of tyrphostins to inhibit phosphorylation of p43 and p20 when induced by thrombin but not when induced by PMA confirms that PTKs may be involved subsequent to PKC activation. | Tyrphostins | coagulation factor II, thrombin | Homo sapiens |