PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1382425-1	1992	Protein tyrosine kinase (PTK) blockers (tyrphostins) inhibit in a dose-dependent fashion thrombin-induced aggregation and serotonin release with IC50 values in the 10-35 microM concentration range.	Tyrphostins	40-51	coagulation factor II, thrombin	Homo sapiens	89-97	
1382425-4	1992	Tyrphostins decreased [32P]phosphatidic acid production induced by thrombin, although never by more than 50%, and only delayed the peak of diacylglycerol, suggesting that phospholipase C was still activated.	Tyrphostins	0-11	coagulation factor II, thrombin	Homo sapiens	67-75	
1382425-5	1992	Tyrphostins inhibited the thrombin-elicited early phosphorylation of p43 and p20, substrates for protein kinase C (PKC) and myosin light chain kinase, respectively, at short times of activation.	Tyrphostins	0-11	coagulation factor II, thrombin	Homo sapiens	26-34	
1382425-9	1992	The ability of tyrphostins to inhibit phosphorylation of p43 and p20 when induced by thrombin but not when induced by PMA confirms that PTKs may be involved subsequent to PKC activation.	Tyrphostins	15-26	coagulation factor II, thrombin	Homo sapiens	85-93