Pub. Date : 1992 Jun 5
PMID : 1375932
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PPIase activity of FKBP25 was far more sensitive to inhibition by rapamycin (IC50 = 50 nM) than FK506 (IC50 = 400 nM). | Tacrolimus | FKBP prolyl isomerase 3 | Homo sapiens |
| 2 | PPIase activity of 100 nM FKBP25 was almost completely inhibited by 150 nM rapamycin while only 90% inhibition was achieved by 4 microM FK506. | Tacrolimus | FKBP prolyl isomerase 3 | Homo sapiens |
| 3 | These data demonstrate that FKBP25 has a higher affinity for rapamycin than for FK506 and suggest that this cellular receptor may be an important target molecule for immunosuppression by rapamycin. | Tacrolimus | FKBP prolyl isomerase 3 | Homo sapiens |