PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1375932-6 1992 The PPIase activity of FKBP25 was far more sensitive to inhibition by rapamycin (IC50 = 50 nM) than FK506 (IC50 = 400 nM). Tacrolimus 100-105 FKBP prolyl isomerase 3 Homo sapiens 23-29 1375932-7 1992 PPIase activity of 100 nM FKBP25 was almost completely inhibited by 150 nM rapamycin while only 90% inhibition was achieved by 4 microM FK506. Tacrolimus 136-141 FKBP prolyl isomerase 3 Homo sapiens 26-32 1375932-8 1992 These data demonstrate that FKBP25 has a higher affinity for rapamycin than for FK506 and suggest that this cellular receptor may be an important target molecule for immunosuppression by rapamycin. Tacrolimus 80-85 FKBP prolyl isomerase 3 Homo sapiens 28-34