Title : Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa.

Pub. Date : 2003 Oct 3

PMID : 13679060






6 Functional Relationships(s)
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1 Recent studies from our laboratory demonstrated that Egr-1 is upregulated in the rat duodenal mucosa during cysteamine-induced duodenal ulceration and that antisense egr-1 oligonucleotide aggravates the duodenal ulcers. Cysteamine early growth response 1 Rattus norvegicus
2 Recent studies from our laboratory demonstrated that Egr-1 is upregulated in the rat duodenal mucosa during cysteamine-induced duodenal ulceration and that antisense egr-1 oligonucleotide aggravates the duodenal ulcers. Cysteamine early growth response 1 Rattus norvegicus
3 This study was aimed to determine the effects of cysteamine on redox-sensitive Egr-1 transcriptional activity and on other thiol-containing proteins such as redox factor-1 (Ref-1) and thioredoxin (Trx). Cysteamine early growth response 1 Rattus norvegicus
4 Here we demonstrate for the first time that cysteamine increases the expression and nuclear translocation of Egr-1, Ref-1, and Trx, and activates binding of Egr-1 to DNA. Cysteamine early growth response 1 Rattus norvegicus
5 Here we demonstrate for the first time that cysteamine increases the expression and nuclear translocation of Egr-1, Ref-1, and Trx, and activates binding of Egr-1 to DNA. Cysteamine early growth response 1 Rattus norvegicus
6 Moreover, we also show that Egr-1 forms a complex with other redox-sensitive transcription factors (e.g., AP-1, AP-2, NFATc, Sp1, PAX-5, MTF-1, c-Myb, and CREB) in rat duodenal mucosa and that cysteamine enhances the formation of these complexes. Cysteamine early growth response 1 Rattus norvegicus