Protein Name early growth response 1
Organism Rattus norvegicus
Gene ID 24330
Gene Symbol

Egr1

UniProt P08154 (EGR1_RAT)
Relationships Total Number of functionally related compound(s) : 338
Total Number of Articles : 488
Description

early growth response 1

Gene Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of macromolecule metabolic process; and regulation of synaptic plasticity. Located in cytoplasm and nucleus. Biomarker of several diseases, including liver cirrhosis; lung disease (multiple); middle cerebral artery infarction; pulmonary hypertension; and visual epilepsy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • early growth response protein 1
  • nerve growth factor-induced protein A
  • transcription factor Zif268
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Properties