Pub. Date : 2004 Jan
PMID : 12969890
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The goal of this study was to determine whether the protein kinase A (PKA) responsiveness of the cardiac L-type Ca(2+) current (ICa) is affected during transient increases in intracellular Ca(2+) concentration. | isocyanic acid | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 2 | The goal of this study was to determine whether the protein kinase A (PKA) responsiveness of the cardiac L-type Ca(2+) current (ICa) is affected during transient increases in intracellular Ca(2+) concentration. | isocyanic acid | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 3 | When measured in 1 or 2 mM Ca(2+) external solution, the aligned myocytes displayed a large ICa that was weakly regulated (20% increase) during stimulation of PKA by 2 microM forskolin. | isocyanic acid | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 4 | The responsiveness of ICa to PKA was restored during intracellular dialysis with a calmodulin (CaM) inhibitory peptide but not during treatment with inhibitors of protein kinase C, Ca(2+)/CaM-dependent protein kinase, or calcineurin. | isocyanic acid | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 5 | Adenoviral-mediated expression of a CaM molecule with mutations in all four Ca(2+)-binding sites also increased the PKA sensitivity of ICa. | isocyanic acid | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 6 | Thus Ca(2+) entering the myocyte through the voltage-gated Ca(2+) channel regulates the PKA responsiveness of ICa. | isocyanic acid | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |